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Article Myelodysplasia associated with acquired immunodeficiency syndrome. free! 2001
Ryu T, Ikeda M, Okazaki Y, Tokuda H, Yoshino N, Honda M, Kimura S, Miura Y. · Department of Internal Medicine, Social Insurance Chuo General Hospital, Tokyo. · Intern Med. · Pubmed #11518128 links to free full text
Abstract: Two cases of acquired immunodeficiency syndrome with myelodysplasia are presented. Case 1 was admitted because of Pneumocystis carinii pneumonia. Mild anemia, thrombocytopenia and hypersegmented neutrophils were observed. After the administration of trimethoprim-sulfame-thoxazole and antiretroviral therapy, pancytopenia progressed. Bone marrow (BM) showed dysplastic hematopoiesis, suggesting human immunodeficiency virus-myelopathy. Case 2 was hospitalized due to progressive multifocal leukoencephalopathy. BM specimen obtained for thrombocytopenia showed myelodysplasia similar to myelodysplastic syndrome, suggesting that HIV may have an influence on hematopoietic progenitor cells.
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Article Direct detection of apoptotic cells in peripheral blood from highly pathogenic SHIV-inoculated monkey. 2000
Yoshino N, Ryu T, Sugamata M, Ihara T, Ami Y, Shinohara K, Tashiro F, Honda M. · AIDS Research Center, Division of Experimental Animal Research, Division of Biosafety Control and Research, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, 162-8640, Japan. · Biochem Biophys Res Commun. · Pubmed #10679297 No free full text.
Abstract: Apoptosis in peripheral blood leukocytes (PBL) has been estimated by the enhancement of spontaneous apoptosis after in vitro culture, because apoptotic cells have not been observed directly in freshly isolated PBL in the course of HIV/AIDS. In monkeys infected with a highly pathogenic simian/human immunodeficiency virus (SHIV), which corresponds to rapid progressors of HIV infection, a high frequency of apoptotic cells was directly detected in fresh PBL by electron-microscopic studies. Peripheral blood apoptosis transiently occurred after intense plasma viremia, and peaking at 3 weeks postinfection; occurrence was not limited specifically to lymphocytes, but also occurred in other types of leukocytes. Apoptosis in peripheral lymph nodes was also detected following intense plasma viremia. However, the in vivo apoptosis was not detected in nonpathogenic SHIV-infected monkeys that showed no cell loss. Thus, we directly showed the apoptosis of PBL, which might be associated with pathogenic SHIV produced during the time of plasma viremia.
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